Interleukin-17-producing cd + T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-b

@inproceedings{Han2010Interleukin17producingC,
  title={Interleukin-17-producing cd + T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-b},
  author={Gencheng Han and Renxi Wang and Guojiang Chen and Jian'an Wang and Ruonan Xu and Liyan Wang and Jiannan Feng and Xia Chong Li and Renfeng Guo and Li Fu and Beifen Shen and Yan Li},
  year={2010}
}
The non-obese diabetic (NOD) mouse spontaneously develops autoimmune diabetes and represents a good model for human type 1 diabetes. The pathogenic roles of T helper type 1 (Th1) cells in autoimmune diabetes have been well defined. Th1 cell cytokines, such as interleukin (IL)-12 and interferon (IFN)-c, have been implicated in promoting diabetogenesis, although there have been recent reports that IFN-c is non-pathogenic in the later phase of diabetes. Therapies designed to balance the Th1/Th2… CONTINUE READING

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