Interleukin-17 in pulmonary host defense.

  title={Interleukin-17 in pulmonary host defense.},
  author={Shean J. Aujla and Patricia J. Dubin and Jay K Kolls},
  journal={Experimental lung research},
  volume={33 10},
Interleukin (IL)-17A and IL-17F are produced by a novel class of effector alphabeta T cells called Th17 cells as well as gammadelta T cells. alphabeta IL-17-producing T cells are controlled by the transcription factor RORgammat and develop independent of GATA-3, T-bet, Stat 4, and Stat 6. Effector molecules produced by these cells include IL-17A, IL-17F, and IL-22. IL-17A and IL-17F bind to IL-17 receptor (IL-17R) and receptor signaling is critical for host defense against extracellular… CONTINUE READING
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