Interleukin-17 in post-stroke neurodegeneration.

  title={Interleukin-17 in post-stroke neurodegeneration.},
  author={Walter Swardfager and Daniel A. Winer and Nathan Herrmann and Shawn Winer and Krista L. Lanct{\^o}t},
  journal={Neuroscience and biobehavioral reviews},
  volume={37 3},
Stroke is a leading cause of physical disability with neurodegenerative sequelae such as dementia and depression causing significant excess morbidity. Stroke severity can be exacerbated by apoptotic cell death in ischemic tissue, of which inflammatory activity is a key determinant. Studies have identified harmful and beneficial sets of T lymphocytes that infiltrate the brain post-stroke and their activation signals, suggesting that they might be targeted for therapeutic benefit. Animal models… CONTINUE READING
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