Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.

Abstract

BACKGROUND Atherosclerosis is an inflammatory disease in which interferon (IFN)-gamma, the signature cytokine of Th1 cells, plays a central role. We investigated whether interleukin (IL)-17, the signature cytokine of Th17 cells, is also associated with human coronary atherosclerosis. METHODS AND RESULTS Circulating IL-17 and IFN-gamma were detected in a… (More)
DOI: 10.1161/CIRCULATIONAHA.108.827618

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@article{Eid2009Interleukin17AI, title={Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.}, author={Raymond E. Eid and Deepak A Rao and Jing Zhou and Sheng-fu Larry Lo and Hooman Ranjbaran and Amy E. Gallo and Seth I Sokol and Steven E Pfau and Jordan S Pober and George Tellides}, journal={Circulation}, year={2009}, volume={119 10}, pages={1424-32} }