Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

@article{Hsu2008Interleukin1T,
  title={Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice},
  author={Hui-Chen Hsu and Pingar Yang and John L. Wang and Qi Wu and Riley C. Myers and Jian Chen and John S Yi and Tanja Guentert and Albert Tousson and Andrea L Stanus and Thuc-vy L. Le and Robin G Lorenz and Hui Xu and Jay K. Kolls and Robert H. Carter and David D. Chaplin and Robert W. Williams and John D Mountz},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={166-175}
}
Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and defense against some bacteria. Here we show that IL-17 can promote autoimmune disease through a mechanism distinct from its proinflammatory effects. As compared with wild-type mice, autoimmune BXD2 mice express more IL-17 and show spontaneous development of germinal centers (GCs) before they increase production of pathogenic autoantibodies. We show that blocking IL-17 signaling disrupts CD4+ T cell and B cell… 
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