Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

@article{Harrington2005Interleukin1C,
  title={Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages},
  author={Laurie E. Harrington and Robin D. Hatton and Paul R. Mangan and Henrietta Turner and Theresa L. Murphy and Kenneth M. Murphy and Casey T. Weaver},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={1123-1132}
}
CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells… 
Late developmental plasticity in the T helper 17 lineage.
TLDR
Mice deficient for STAT4 and T-bet-two prototypical Th1 transcription factors are protected from autoimmunity associated with Th17 pathogenesis and support a model of late Th17 developmental plasticity with implications for autoIMmunity and host defense.
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
  • C. Dong
  • Medicine, Biology
    Nature Reviews Immunology
  • 2006
TLDR
It is proposed that IL-17-producing CD4+ T cells represent a distinct inflammatory TH-cell lineage and have crucial roles in regulating tissue inflammation and the development of disease in several animal models of autoimmunity.
Th17 cells: a new fate for differentiating helper T cells
TLDR
Designated Th17 cells, a new lineage of helper T cells, selectively produces proinflammatory cytokines including IL-17, IL-21, and IL-22 and may be beneficial for the treatment of inflammatory and autoimmune diseases.
IL-17 and Th17 Cells.
TLDR
The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
Development, cytokine profile and function of human interleukin 17–producing helper T cells
TLDR
It is demonstrated that IL-23 and IL-1β induced the development of human and mouse TH-17 cells expressing IL-17A,IL-17F, IL-22, Il-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt, and that human TH- 17 cells may regulate innate immunity in epithelial cells.
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TLDR
New data suggest a dichotomy between CD4+ regulatory T cells positive for the transcription factor Foxp3 and TH-17 cells, whereas IL-6 inhibits TGF-β-driven Foxp 3 expression and together with T GF-β induces TH- 17 cells.
Th17 cells: effector T cells with inflammatory properties.
TLDR
Clearly, the specific effector functions of Th17 cells expand beyond previously described effects of Th1 and Th2 immunity, with specific roles in host defense against certain pathogens and in organ-specific autoimmunity.
Transforming growth factor-β induces development of the TH17 lineage
TLDR
Transforming growth factor-β (TGF-β) is identified as a cytokine critical for commitment to TH17 development and provides a mechanism for divergence of the TH1, TH2 and TH17 lineages.
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells
TLDR
It is demonstrated here that IL-6, but not TNF-α or IL-1β, can, in combination with TGF-β, induce Th17 cell generation from naïve T cells and inhibit T GF-β-induced Foxp3 expression.
Th 17 cells : a new fate for di V erentiating helper T cells
Classically naïve CD4+ have been thought to diVerentiate into two possible lineages, T helper 1 (Th1) or T helper 2 (Th2) cells. Within this paradigm the pathogenesis of autoimmunity was suggested to
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