Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

@article{Teague2006Interleukin15RT,
  title={Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors},
  author={R. Teague and B. Sather and Jilian A Sacks and M. Huang and M. L. Dossett and J. Morimoto and Xiaoxio Tan and Susan E. Sutton and M. Cooke and C. Öhlén and P. Greenberg},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={335-341}
}
  • R. Teague, B. Sather, +8 authors P. Greenberg
  • Published 2006
  • Biology, Medicine
  • Nature Medicine
  • CD8+ T cells can mediate eradication of established tumors, and strategies to amplify tumor-reactive T-cell numbers by immunization or ex vivo expansion followed by adoptive transfer are currently being explored in individuals with cancer. Generating effective CD8+ T cell–mediated responses to tumors is often impeded by T-cell tolerance to relevant tumor antigens, as most of these antigens are also expressed in normal tissues. We examined whether such tolerant T cells could be rescued and… CONTINUE READING
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