Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells.

@article{Rausch2006Interleukin15MP,
  title={Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells.},
  author={Alexandra Rausch and Manuela Hessmann and Alexandra H{\"o}lscher and Tanja Schreiber and Silvia Bulfone-Paus and Stefan Ehlers and Christoph Hoelscher},
  journal={European journal of immunology},
  year={2006},
  volume={36 5},
  pages={1156-67}
}
CD8+ T cells are involved in protection against Mycobacterium tuberculosis infection and represent a promising target for new vaccine strategies. Because IL-15 is important for the homeostasis of CD8+ T cells, we studied the immune response in IL-15-deficient mice during tuberculosis. In the absence of IL-15, CD8+ T cells failed to efficiently accumulate in draining lymph nodes and at the site of infection. The expression of antigen-specific effector functions, such as the production of… CONTINUE READING