Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats.

@article{Figueras2004Interleukin15IA,
  title={Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats.},
  author={Maite Figueras and S{\'i}lvia Busquets and Neus Carb{\'o} and Esther Barreiro and Vanessa Almendro and Josep Maria Argil{\'e}s and Francisco Javier L{\'o}pez-Soriano},
  journal={FEBS letters},
  year={2004},
  volume={569 1-3},
  pages={201-6}
}
Administration of interleukin-15 (IL-15) to rats bearing the Yoshida AH-130 ascites hepatoma (a tumour that induces an important cachectic response) resulted in a significant reduction of muscle wasting, both measured as muscle weight and as protein content of different types of skeletal muscle. In addition, the administration of the cytokine completely reversed the increased DNA fragmentation observed in skeletal muscle of tumour-bearing animals. Concerning the mechanism(s) involved in the… CONTINUE READING