Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits.

  title={Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits.},
  author={Takeshi Kubota and Richard A. Brown and Jia Fang and James M. Krueger},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={281 3},
Interleukin (IL)-15 and -2 share receptor- and signal-transduction pathway (Jak-STAT pathway) components. IL-2 is somnogenic in rats but has not been tested in other species. Furthermore, the effects of IL-15 on sleep have not heretofore been described. We investigated the somnogenic actions of IL-15 in rabbits and compared them with those of IL-2. Three doses of IL-15 or -2 (10, 100, and 500 ng) were injected intracerebroventriculary at the onset of the dark period. In addition, 500 ng of IL… CONTINUE READING


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