Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity

  title={Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity},
  author={Nicole G Barra and Rengasamy Palanivel and Emmanuel Denou and Marianne V. Chew and Amy E. Gillgrass and Tina D. Walker and Josh Kong and Carl D Richards and Manel Jordana and Stephen M. Collins and Bernardo Louis Trigatti and Alison C Holloway and Sandeep Raha and Gregory R Steinberg and Ali A Ashkar},
  booktitle={PloS one},
Interleukin-15 (IL-15) is an immunomodulatory cytokine that affects body mass regulation independent of lymphocytes; however, the underlying mechanism(s) involved remains unknown. In an effort to investigate these mechanisms, we performed metabolic cage studies, assessed intestinal bacterial diversity and macronutrient absorption, and examined adipose mitochondrial activity in cultured adipocytes and in lean IL-15 transgenic (IL-15tg), overweight IL-15 deficient (IL-15-/-), and control C57Bl/6… CONTINUE READING
Highly Cited
This paper has 155 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Interleukin-15 in obesity and metabolic dysfunction: current understanding and future perspectives.

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2017
View 6 Excerpts
Highly Influenced

156 Citations

Citations per Year
Semantic Scholar estimates that this publication has 156 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 65 references

Oversecretion of interleukin-15 from skeletal muscle reduces adiposity.

American journal of physiology. Endocrinology and metabolism • 2009
View 5 Excerpts
Highly Influenced

Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine.

Translational research : the journal of laboratory and clinical medicine • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…