Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity

@inproceedings{Barra2014Interleukin15MA,
  title={Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity},
  author={Nicole G Barra and Rengasamy Palanivel and Emmanuel Denou and Marianne V. Chew and Amy E. Gillgrass and Tina D. Walker and Josh Kong and Carl D Richards and Manel Jordana and Stephen M. Collins and Bernardo Louis Trigatti and Alison C Holloway and Sandeep Raha and Gregory R Steinberg and Ali A Ashkar},
  booktitle={PloS one},
  year={2014}
}
Interleukin-15 (IL-15) is an immunomodulatory cytokine that affects body mass regulation independent of lymphocytes; however, the underlying mechanism(s) involved remains unknown. In an effort to investigate these mechanisms, we performed metabolic cage studies, assessed intestinal bacterial diversity and macronutrient absorption, and examined adipose mitochondrial activity in cultured adipocytes and in lean IL-15 transgenic (IL-15tg), overweight IL-15 deficient (IL-15-/-), and control C57Bl/6… CONTINUE READING
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Interleukin-15 in obesity and metabolic dysfunction: current understanding and future perspectives.

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