Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils.

  title={Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils.},
  author={Patrick P McDonald and Maria Pia Russo and Silvano Ferrini and Marco A Cassatella},
  volume={92 12},
Interleukin-2 (IL-2) and IL-15 exert similar biological actions, which largely reflect the fact that their receptors share common beta and gamma subunits; in contrast, distinct subunits are required for high-affinity binding of either cytokine to a heterotrimeric receptor complex. Human neutrophils are known to express both the beta and gamma subunits of the IL-2/IL-15 receptor complex, and we now report that they also constitutively express messenger RNA transcripts encoding the IL-15 receptor… CONTINUE READING

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Cytokines produced by polymorphonuclear neutrophils: Molecular and biological aspects

  • MA Cassatella
  • R.G. Landes Co, Georgetown,
  • 1996

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