Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells.

@article{Epardaud2008Interleukin15interleukin15RAC,
  title={Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells.},
  author={Mathieu Epardaud and Kutlu G. Elpek and Mark P Rubinstein and Ai-ris Yonekura and Ang{\'e}lique Bellemare-Pelletier and Roderick Bronson and Jessica A. Hamerman and Ananda W Goldrath and Shannon J. Turley},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2972-83}
}
Tumors often escape immune-mediated destruction by suppressing lymphocyte infiltration or effector function. New approaches are needed that overcome this suppression and thereby augment the tumoricidal capacity of tumor-reactive lymphocytes. The cytokine interleukin-15 (IL-15) promotes proliferation and effector capacity of CD8(+) T cells, natural killer (NK) cells, and NKT cells; however, it has a short half-life and high doses are needed to achieve functional responses in vivo. The biological… CONTINUE READING
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