Interleukin-13 prevents autoimmune diabetes in NOD mice.

  title={Interleukin-13 prevents autoimmune diabetes in NOD mice.},
  author={Paola Zaccone and Joseph Phillips and Ignacio Conget and Ram{\'o}n Morell Gomis and Kathryn Haskins and Adrian Minty and Klaus Bendtzen and Anne Cooke and Ferdinando Nicoletti},
  volume={48 8},
Interleukin (IL)-13 is a cytokine primarily produced by the T-helper (Th)-2 subset of lymphocytes that possesses powerful anti-inflammatory properties. Here, we have evaluated the impact of IL-13 treatment on development of type 1 diabetes in diabetes-prone nonobese diabetic (NOD) mice. Prolonged treatment with recombinant human IL-13 (hIL-13) markedly diminished the incidence of spontaneous type 1 diabetes in the mice. Female NOD mice treated from age 5-16 weeks with hIL-13 also showed… CONTINUE READING