Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

@article{Lee2001Interleukin13ID,
  title={Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.},
  author={Janet H. Lee and Naftali Kaminski and Gregory Dolganov and Gabriele Grunig and Laura L Koth and Claire Solomon and David J. Erle and Dean Sheppard},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={25 4},
  pages={474-85}
}
Interleukin (IL)-13, a cytokine released by T lymphocytes during immediate hypersensitivity responses, is a central mediator of asthma. Because IL-13 induces phenotypic features of asthma in mice deficient in T and B lymphocytes, it is likely that this cytokine contributes to the development of asthma by acting directly on resident airway cells. To analyze the global effects of IL-13 on gene expression in airway cells that could contribute to the phenotypic features of asthma, we used Genechip… CONTINUE READING

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