Interleukin-13 in asthma pathogenesis.

  title={Interleukin-13 in asthma pathogenesis.},
  author={Marsha Wills-Karp},
  journal={Immunological reviews},
Bronchial asthma is a complex disorder that is thought to arise as a result of aberrant T-lymphocyte responses to noninfectious environmental antigens. In particular, the symptoms of asthma are closely associated with the presence of activated T-helper 2 cell (Th2) cytokine-producing cells [interleukin (IL)-4, IL-5, IL-9, and IL-13] in the airway wall. Although each of the Th2 cytokines likely contributes to the overall immune response directed against environmental antigens, a substantial body… CONTINUE READING
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