Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype.

@article{Faffe2006Interleukin13AI,
  title={Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype.},
  author={D{\'e}bora Souza Faffe and Lesley Flynt and Kerri Bourgeois and Reynold A Panettieri and Stephanie A. Shore},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={34 2},
  pages={213-8}
}
Th2 cytokines induce the release of vascular endothelial growth factor (VEGF) from cultured human airway smooth muscle cells. The objective of this study was to examine the mechanistic basis for IL-4- and IL-13-induced VEGF release and to determine whether genetic differences are responsible for donor-to-donor variability in VEGF release. We measured VEGF mRNA expression by real-time PCR, mRNA stability using actinomycin D, and promoter activity with a VEGF-promoter luciferase reporter… CONTINUE READING