Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.

Abstract

Nematode infection upregulates interleukin-4 (IL-4) and IL-13 and induces STAT6-dependent changes in gut function that promote worm clearance. IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13Rα1 and IL-4Rα chains. We used mice deficient in IL-13Rα1 (IL-13Rα1(-/-)) to examine the contribution of IL-13 acting at the type 2 IL… (More)
DOI: 10.1128/IAI.00990-15

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Cite this paper

@article{Sun2016Interleukin13R, title={Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.}, author={Rex Sun and Joseph J. Urban and Luigi Notari and Tim Vanuytsel and Kathleen B. Madden and Jennifer Ann Bohl and Thirumalai R. Ramalingam and Thomas A. Wynn and Aiping Zhao and T Shea-Donohue}, journal={Infection and immunity}, year={2016}, volume={84 4}, pages={1032-44} }