Interleukin-12. Biologic activity, therapeutic utility, and role in disease.

  title={Interleukin-12. Biologic activity, therapeutic utility, and role in disease.},
  author={Jill A. Hendrzak and Michael J. Brunda},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={72 6},
IL-12 is a heterodimeric cytokine that promotes cell-mediated immunity through its regulatory effects on T and NK cells. In some murine infectious disease models, IL-12 was shown to be produced endogenously in response to infection, and the exogenous administration of IL-12 to mice with either infectious diseases or tumors has resulted in significant therapeutic effects. IL-12 was protective early in the disease process, as well as against established disease. However, the biologic activities… CONTINUE READING

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