Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury.

@article{OSilleabhin1996Interleukin12TR,
  title={Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury.},
  author={Criost{\'o}ir O'S{\'u}illeabh{\'a}in and Suzanne O'Sullivan and John L. Kelly and James A. Lederer and John A. Mannick and Mary L. Rodrick},
  journal={Surgery},
  year={1996},
  volume={120 2},
  pages={
          290-6
        }
}
BACKGROUND Preliminary studies in this laboratory have shown that treatment with interleukin-12 (IL-12), a cytokine that induces expression of the T-helper-1 lymphocyte phenotype, in an animal model of burn injury increased survival after a septic challenge. The purpose of this study was to define the efficacy of IL-12 therapy and to explore its mechanism of action. METHODS Adult male A/J mice were subjected to 25% full-thickness scald or sham burn. Starting on day 3 after burn, groups of… CONTINUE READING
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