Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis.

@article{Murray2000Interleukin12RT,
  title={Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis.},
  author={Henry W. Murray and C Montelibano and Ron Peterson and Joseph P. Sypek},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={182 5},
  pages={1497-502}
}
In experimental visceral leishmaniasis, interleukin (IL)-12 initiates control over Leishmania donovani via Th1 cell activation, interferon (IFN)-gamma secretion, and granuloma formation. Because the leishmanicidal effect of conventional therapy, pentavalent antimony (Sb), also requires T cells and endogenous IFN-gamma, we tested IL-12 as a determinant of host responsiveness to chemotherapy. L. donovani-challenged IL-12p35 gene knockout (KO) mice permitted uncontrolled hepatic infection and… CONTINUE READING