Interleukin-12 promotes a chronic intestinal nematode infection.

  title={Interleukin-12 promotes a chronic intestinal nematode infection.},
  author={Allison J Bancroft and Kathryn J. Else and Joseph P. Sypek and Richard K Grencis},
  journal={European journal of immunology},
  volume={27 4},
Resistance and susceptibility to the intestinal parasite Trichuris muris has been shown to be due to a dominant T helper 2 (Th2) and a dominant Th1 response, respectively. The factors determining the initial polarization of the immune response remain largely unresolved, although the cytokine environment at the time of antigen presentation clearly plays an essential role. Interleukin (IL)-12, a cytokine produced mainly by macrophages, dendritic cells, and other monocytes has been shown to be… CONTINUE READING