Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

@article{Heufler1996Interleukin12IP,
  title={Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.},
  author={Christine Heufler and Franz Koch and Ursula Stanzl and Gerda Topar and Maria Wysocka and Giorgio Trinchieri and Alexander H Enk and Ralph Marvin Steinman and Nikolaus Romani and Gerold Schuler},
  journal={European journal of immunology},
  year={1996},
  volume={26 3},
  pages={659-68}
}
Interleukin-12 (IL-12), a 70-kDa heterodimeric cytokine composed of covalently linked p35 and p40 chains, is to date the most critical factor for skewing the immune response towards a T helper 1 (Th1) of cytokine profile [high interferon-gamma (IFN-gamma), low IL-4]. Established sources of IL-12 are stimulated macrophages, neutrophils and B cells. As dendritic cells (DC) process antigen in the periphery and then migrate to lymphoid organs to sensitize T cells and induce cell mediated immunity… CONTINUE READING
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