Interleukin 12 induction of interferon gamma-dependent protection against malaria.

  title={Interleukin 12 induction of interferon gamma-dependent protection against malaria.},
  author={Martha Sedegah and Fred D. Finkelman and Stephen L Hoffman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 22},
Intraperitoneal injection of recombinant Interleukin 12 (rIL-12) at 30 ng/day for 5 days beginning 1 to 2 days before sporozoite challenge or administration of a single dose of 150 ng of rIL-122 days before challenge protected 100% of BALB/c mice against challenge with 10(2) Plasmodium yoelii sporozoites. rIL-12-induced protection was eliminated in all mice by administration of a monoclonal antibody against interferon gamma and in 50% of mice by administration of NG-monomethyl-L-arginine, a… CONTINUE READING
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