Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

@article{Manetti1994Interleukin1I,
  title={Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones},
  author={Roberto Manetti and Franca Gerosa and Maria Grazia Giudizi and Roberta Biagiotti and Paola Parronchi and M P Piccinni and Salvatore Sampognaro and Enrico Maggi and Sergio Romagnani and Giorgio Trinchieri},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={1273 - 1283}
}
Interleukin 12 (IL-12) facilitates the generation of a T helper type 1 (Th1) response, with high interferon gamma (IFN-gamma) production, while inhibiting the generation of IL-4-producing Th2 cells in polyclonal cultures of both human and murine T cells and in vivo in the mouse. In this study, we analyzed the effect of IL-12, present during cloning of human T cells, on the cytokine profile of the clones. The culture system used allows growth of clones from virtually every T cell, and thus… CONTINUE READING
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IL-12 acts directly on CD4 § T cells to enhance priming for IFN-3' production and diminkhes 11,4 inhibition of such priming

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Ib 12 functions as an effective adjuvant in a vaccine against Leishmania major by directing the development of leishmanial specific CD 4 § Thl cells

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Ib12 functions as an effective adjuvant in a vaccine against Leishmania major by directing the development of leishmanial specific CD4

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