Interleukin-12 genetic administration suppressed metastatic liver tumor unsusceptible to CTL.

@article{Itokawa2004Interleukin12GA,
  title={Interleukin-12 genetic administration suppressed metastatic liver tumor unsusceptible to CTL.},
  author={Yoshiki Itokawa and Osam Mazda and Yoshiko Ueda and Tsunao Kishida and Hidetsugu Asada and Feng De Cui and Nobuaki Fuji and Hitoshi Fujiwara and Masaharu Shin-Ya and Kakei Yasutomi and Jiro Imanishi and Hisakazu Yamagishi},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={314 4},
  pages={
          1072-9
        }
}
A cytokine gene therapy approach was conducted against metastatic lesions of cytotoxic T lymphocyte (CTL)-unsusceptible tumor in mice. The EBV-based and conventional plasmid vectors that encode murine interleukin-12 (IL-12) gene (pGEG.mIL-12 and pG.mIL-12, respectively) were intravenously transfected into the mice that had received a subcutaneous inoculation of M5076 sarcoma cells. The pGEG.mIL-12 transfection drastically suppressed the subcutaneous as well as hepatic metastatic tumors… CONTINUE READING
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