Interleukin-12 gene therapy prevents establishment of SCC VII squamous cell carcinomas, inhibits tumor growth, and elicits long-term antitumor immunity in syngeneic C3H mice.

@article{Myers1998Interleukin12GT,
  title={Interleukin-12 gene therapy prevents establishment of SCC VII squamous cell carcinomas, inhibits tumor growth, and elicits long-term antitumor immunity in syngeneic C3H mice.},
  author={Jeffrey N. Myers and Amy R Mank-Seymour and Laurence Zitvogel and Walter Storkus and Martha R. Clarke and Candace S. Johnson and Hideaki Tahara and Michael T Lotze},
  journal={The Laryngoscope},
  year={1998},
  volume={108 2},
  pages={261-8}
}
Interleukin-12 (IL-12) is an immunostimulatory agent with very promising antitumor activity. Using a retroviral expression vector, the authors have successfully transduced the genes encoding the two subunits of murine IL-12 to the squamous cell carcinoma cell line, SCC VII. Once IL-12 gene transcription and protein production were successfully verified, IL-12 expression was found to inhibit the establishment of SCC VII tumors in syngeneic C3H/HeJ mice inoculated with 1 x 10(6) SCC VII/IL-12… CONTINUE READING

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