Interleukin-12 and the regulation of innate resistance and adaptive immunity

@article{Trinchieri2003Interleukin12AT,
  title={Interleukin-12 and the regulation of innate resistance and adaptive immunity},
  author={Giorgio Trinchieri},
  journal={Nature Reviews Immunology},
  year={2003},
  volume={3},
  pages={133-146}
}
  • Giorgio Trinchieri
  • Published in Nature Reviews Immunology 2003
  • Biology, Medicine
  • Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and forms a link between innate resistance and adaptive immunity. Dendritic cells (DCs) and phagocytes produce IL-12 in response to pathogens during infection. Production of IL-12 is dependent on differential mechanisms of regulation of expression of the genes encoding IL-12, patterns of Toll-like receptor (TLR) expression… CONTINUE READING

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