Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors.

@article{Zitvogel1996Interleukin12AB,
  title={Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors.},
  author={Laurence Zitvogel and P. David Robbins and Walter J. Storkus and Martha R. Clarke and Markus Maeurer and Robert L. Campbell and C. G. Davis and Hideaki Tahara and Robert D Schreiber and Michael T Lotze},
  journal={European journal of immunology},
  year={1996},
  volume={26 6},
  pages={1335-41}
}
Interleukin-12 (IL-12) promotes specific and long-lasting anti-tumor immunity mediated by T cells in a variety of murine tumor models. IL-12 also synergizes with B7.1 (CD80) co-stimulation to induce proliferation and cytokine production by both human and murine T cells in vitro. We evaluated the combined anti-tumor efficacy of IL-12 and B7.1 gene delivery in two apparently poorly immunogenic tumor models (TS/A and MCA207). In both of these models, expression of B7.1 and production of IL-12 in… CONTINUE READING

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