Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.

@article{Takeuchi2002Interleukin11AA,
  title={Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.},
  author={Yasuhiro Takeuchi and Sumiyo Watanabe and Genichiro Ishii and Shu Takeda and Konosuke Nakayama and Seiji Fukumoto and Yasuyuki Kaneta and D Inoue and Toshio Matsumoto and Kenichi Harigaya and Toshiro Fujita},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 50},
  pages={49011-8}
}
Cytokines in interleukin (IL)-11 subfamily participate in the regulation of bone cell proliferation and differentiation. We report here positive effects of IL-11 on osteoblasts and bone formation. Overexpression of human IL-11 gene in transgenic mice resulted in the stimulation of bone formation to increase cortical thickness and strength of long bones, and in the prevention of cortical bone loss with advancing age. Bone resorption and osteoclastogenesis were not affected in IL-11 transgenic… CONTINUE READING
40 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…