Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders.

@article{Nelson2000Interleukin1T,
  title={Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders.},
  author={David R. Nelson and Gregory Yves Lauwers and Johnson Y. N. Lau and Gary L. Davis},
  journal={Gastroenterology},
  year={2000},
  volume={118 4},
  pages={655-60}
}
BACKGROUND & AIMS Interleukin (IL)-10 is a cytokine that down-regulates the proinflammatory response and has a modulatory effect on hepatic fibrogenesis. The aim of this study was to determine the effect of IL-10 on hepatic injury in patients with chronic hepatitis C. METHODS Twenty-four patients with chronic hepatitis C who had not previously responded to interferon-based therapy were enrolled in a randomized, double-blinded 2-dose trial in which they received either 4 or 8 microgram/kg IL… CONTINUE READING

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