Interleukin-10 suppression of myeloid cell activation--a continuing puzzle.

  title={Interleukin-10 suppression of myeloid cell activation--a continuing puzzle.},
  author={Lynn M. Williams and Giuseppe A Ricchetti and U. M. B. S. Sarma and Timothy Smallie and Brian M. J. Foxwell},
  volume={113 3},
Efforts to identify the signal transduction pathways used by interleukin-10 (IL-10) have resulted in limited success. The anti-inflammatory effects elicited by IL-10, and the mechanisms by which these are mediated, are still relatively unknown. Understanding the signalling mechanisms behind the suppression of cytokine expression by IL-10 could be of potential therapeutic interest. Although the consensus is that the Janus kinase, Jak1, as well as the signal transducer and activator of… CONTINUE READING


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