Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells.

  title={Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells.},
  author={Yongpeng Gu and Jianfei Yang and Xinshou Ouyang and Weicheng Liu and Hongxing Li and Jianjun Yang and Jonathan Bromberg and Shu-hsia Chen and Lloyd Hitoshi Mayer and Jay C. Unkeless and Huabao Xiong},
  journal={European journal of immunology},
  volume={38 7},
IL-17 and IL-22 are typical cytokines produced by the Th17 T cell subset, but it is unclear if Th17 cytokines can be produced by other cell types. We demonstrate that IL-10-deficient and IL-10R-deficient macrophages stimulated with lipopolysaccharide produce high levels of IL-17 and IL-22. Addition of exogenous IL-10 to IL-10-deficient macrophages abolished IL-17 production. When IL-10-deficient and IL-10R-deficient splenocytes were cultured under Th17 polarizing conditions, the population of… CONTINUE READING


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