Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.

  title={Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.},
  author={Brian D. Shames and Craig H. Selzman and Daniel R. Meldrum and Edward J Pulido and Hazel A. Barton and Xianzhong Meng and Alden Hood Harken and Robert C. McIntyre},
  volume={10 6},
Interleukin-10 (IL-10) protects animals from lethal endotoxemia. This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha). Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism. NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
21 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…