Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.

@article{Shames1998Interleukin10SI,
  title={Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.},
  author={Brian D. Shames and Craig H. Selzman and Daniel R. Meldrum and Edward J Pulido and Hazel A. Barton and Xianzhong Meng and Alden Hood Harken and Robert C. McIntyre},
  journal={Shock},
  year={1998},
  volume={10 6},
  pages={389-94}
}
Interleukin-10 (IL-10) protects animals from lethal endotoxemia. This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha). Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism. NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB… CONTINUE READING
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