Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.

@article{Chaudhry2011Interleukin10SI,
  title={Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.},
  author={Ashutosh Chaudhry and Robert M Samstein and Piper R. Treuting and Yuqiong Liang and Marina C. Pils and J. Heinrich and Robert Smail Jack and F Thomas Wunderlich and Jens C. Br{\"u}ning and Werner M{\"u}ller and Alexander Y Rudensky},
  journal={Immunity},
  year={2011},
  volume={34 4},
  pages={
          566-78
        }
}
Effector CD4+ T cell subsets, whose differentiation is facilitated by distinct cytokine cues, amplify the corresponding type of inflammatory response. Regulatory T (Treg) cells integrate environmental cues to suppress particular types of inflammation. In this regard, STAT3, a transcription factor essential for T helper 17 (Th17) cell differentiation, is necessary for Treg cell-mediated control of Th17 cell responses. Here, we showed that anti-inflammatory interleukin-10 (IL-10), and not… CONTINUE READING
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