Interleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia/reperfusion.

@article{Lane1997Interleukin10RT,
  title={Interleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia/reperfusion.},
  author={J. Scott Lane and Karen E. Todd and Mark P Lewis and Beat Gloor and Stanley W Ashley and Howard A. Reber and David W. Mcfadden and Charles F. Chandler},
  journal={Surgery},
  year={1997},
  volume={122 2},
  pages={288-94}
}
BACKGROUND Intestinal ischemia/reperfusion (I/R) is known to increase systemic cytokine levels, as well as to activate neutrophils in distant organs. This study was designed to investigate the effect of interleukin-10 (IL-10) on cytokine release, pulmonary neutrophil accumulation, and histologic changes in a murine model of I/R. METHODS Forty female Swiss-Webster mice were divided into four groups. Group 1 underwent 45 minutes of superior mesenteric artery occlusion followed by 3-hour… CONTINUE READING

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