Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice.

  title={Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice.},
  author={Salim A Kanaan and Steve Poole and Nayef E. Saad{\'e} and Suhayl J Jabbur and Bared Safieh-Garabedian},
  journal={Journal of neuroimmunology},
  volume={86 2},
In the endotoxin-induced inflammation, interleukin-10 reduced significantly, and in a dose-dependent manner, the inflammatory pain as assessed by mechanical and thermal tests. The levels of Tumour Necrosis Factor (TNF)alpha and NGF were upregulated at 1.5 h whereas those of IL-1beta at 6 h after ET injection. IL-10 downregulated the levels of TNFalpha (from… CONTINUE READING