Interleukin-10 provides direct trophic support to neurons.

  title={Interleukin-10 provides direct trophic support to neurons.},
  author={Zhigang Zhou and Xiangmin Peng and Ryan Insolera and David J. Fink and Marina Mata},
  journal={Journal of neurochemistry},
  volume={110 5},
Interleukin (IL)-10, a prototypical anti-inflammatory cytokine, has been shown to provide beneficial effects in neuronal injury in vivo but the full range of actions has not been established. In order to understand the neuronal mechanisms underlying IL-10-mediated neuroprotection, we examined the effect of IL-10 on primary neurons in culture. We found that IL-10 exerted a direct trophic influence on spinal cord neurons, and that activation of the neuronal IL-10 receptor provided trophic support… CONTINUE READING


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