Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands.

@article{Rosado2008Interleukin10PP,
  title={Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands.},
  author={S{\'i}lvia Rosado and {\'I}{\~n}igo R{\'u}a-Figueroa and Juan A. Vargas and M Isabel Garc{\'i}a-Laorden and Ignacio Losada-Fern{\'a}ndez and Trinidad Mart{\'i}n-Donaire and Gema P{\'e}rez-Chac{\'o}n and Carlos Rodr{\'i}guez-Gallego and Antonio Naranjo-Hern{\'a}ndez and Soledad Ojeda-Bruno and Mar{\'i}a Jes{\'u}s Citores and Paloma Perez-Aciego},
  journal={International journal of immunogenetics},
  year={2008},
  volume={35 3},
  pages={235-42}
}
The purpose of this study was to examine whether several allelic variants in the polymorphic interleukin (IL)-10 promoter region were related with an increased risk of developing systemic lupus erythematosus (SLE) in Spanish patients from Canary Islands. Microsatellites (MS) at positions -4000 and -1200 (IL10R and IL10G, respectively) and single nucleotide polymorphisms (SNPs) (MS) at positions -1082G/A, -819C/T and -592C/A of the IL-10 promoter were analysed in patients with SLE and healthy… CONTINUE READING
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