Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease

  title={Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease},
  author={Domenico Lio and Federico Licastro and Letizia Scola and Martina Chiappelli and Luigi Grimaldi and Antonio Crivello and Giuseppina Colonna-Romano and G Candore and Claudio Franceschi and Calogero Caruso},
  journal={Genes and Immunity},
Proinflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their high production have been shown to be associated with AD. Thus, AD patients display a proinflammatory genotype and the control of inflammation might play a protective role in AD development. By sequence-specific probes, we have evaluated the role of anti-inflammatory cytokine interleukin(IL)-10 in AD, by analysing in 132 AD… CONTINUE READING