Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion.

@article{Madsen1997Interleukin1P,
  title={Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion.},
  author={Karen L Madsen and Simon A. Lewis and Michele M. Tavernini and Jennifer Hibbard and Richard N Fedorak},
  journal={Gastroenterology},
  year={1997},
  volume={113 1},
  pages={151-9}
}
BACKGROUND & AIMS The proinflammatory cytokine interferon gamma (IFN-gamma) disrupts epithelial barrier integrity and attenuates secretagogue-induced chloride secretion. This study tested the efficacy of the anti-inflammatory cytokine interleukin 10 (IL-10) in maintaining epithelial barrier and chloride secretory function in the presence of IFN-gamma. METHODS T84 epithelial cell monolayers were treated with IL-10, IFN-gamma, or IFN-gamma plus IL-10. Monolayer barrier integrity was assessed by… CONTINUE READING