Interleukin-10 plays an early role in generating virus-specific T cell anergy

  title={Interleukin-10 plays an early role in generating virus-specific T cell anergy},
  author={Charles H. Maris and Craig P. Chappell and Joshy Jacob},
  journal={BMC Immunology},
  pages={8 - 8}
Infection of mice with the Armstrong strain of lymphocytic choriomeningitis virus (LCMVARM) leads to a robust immune response and efficient viral clearance. This is in contrast to infection with the variant strain LCMVClone13, which causes functional inactivation of effector T cells and viral persistence. The mechanism by which LCMVClone13 suppresses the antiviral immune response and persists in its host is unknown. Here we demonstrate that infection with LCMVClone13, but not with LCMVARM… CONTINUE READING


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