Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice.

@article{Gudmundsson1998Interleukin10MT,
  title={Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice.},
  author={G Steinar Gudmundsson and Andrea Bosch and Beverly L. Davidson and Daniel J. Berg and Gary W. Hunninghake},
  journal={American journal of respiratory cell and molecular biology},
  year={1998},
  volume={19 5},
  pages={812-8}
}
Hypersensitivity pneumonitis (HP) is an inflammatory lung disease characterized by granuloma formation. We recently showed that interferon-gamma (IFN-gamma) is essential for inflammation and granuloma formation in HP. Interleukin-10 (IL-10) counteracts many of the biologic effects of IFN-gamma, suggesting that IL-10 modulates inflammation and granuloma formation in HP. We compared the expression of HP in C57BL/6 mice that lack IL-10 (IL-10 knockout [KO]) with that in wild-type (WT) littermates… CONTINUE READING