Interleukin-10-mediated inhibition of free radical generation in macrophages.

  title={Interleukin-10-mediated inhibition of free radical generation in macrophages.},
  author={Sujatha Dokka and Xianglin Shi and Stephen S. Leonard and Liying Wang and Vincent Castranova and Yon Rojanasakul},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={280 6},
Interleukin-10 (IL-10) is a pleiotropic cytokine that controls inflammatory processes by suppressing the production of proinflammatory cytokines that are known to be transcriptionally regulated by nuclear factor-kappaB (NF-kappaB). Although still controversial, IL-10 has been shown to inhibit NF-kappaB activation through a process that involves proteolytic degradation of inhibitory subunit IkappaB-alpha. What is not known, however, is the mechanism by which IL-10 exerts its effect on IkappaB… CONTINUE READING


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