Interleukin-10-mediated inhibition of free radical generation in macrophages.

@article{Dokka2001Interleukin10mediatedIO,
  title={Interleukin-10-mediated inhibition of free radical generation in macrophages.},
  author={Sujatha Dokka and Xianglin Shi and Stephen S. Leonard and Liying Wang and Vincent Castranova and Yon Rojanasakul},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 6},
  pages={L1196-202}
}
Interleukin-10 (IL-10) is a pleiotropic cytokine that controls inflammatory processes by suppressing the production of proinflammatory cytokines that are known to be transcriptionally regulated by nuclear factor-kappaB (NF-kappaB). Although still controversial, IL-10 has been shown to inhibit NF-kappaB activation through a process that involves proteolytic degradation of inhibitory subunit IkappaB-alpha. What is not known, however, is the mechanism by which IL-10 exerts its effect on IkappaB… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 34 references

Function and activation of NF-kappa B in the immune system.

Annual review of immunology • 1994
View 6 Excerpts
Highly Influenced

14-3-3 proteins: structure, function, and regulation.

Annual review of pharmacology and toxicology • 2000
View 1 Excerpt

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