Interleukin-10-mediated T cell apoptosis during the T helper type 2 cytokine response in murine Schistosoma mansoni parasite infection.

@article{Estaquier1997Interleukin10mediatedTC,
  title={Interleukin-10-mediated T cell apoptosis during the T helper type 2 cytokine response in murine Schistosoma mansoni parasite infection.},
  author={J{\'e}r{\^o}me Estaquier and Miss Marguerite and Florent Sahuc and Natacha Bessis and Claude Auriault and Jean Claude Ameisen},
  journal={European cytokine network},
  year={1997},
  volume={8 2},
  pages={153-60}
}
The pathogenesis of infection with the helminth parasite Schistosoma (S) mansoni in mice has been reported to involve a T helper (Th)1 to Th2 cytokine switch, associated with a pathogenic granulomatous response to parasite eggs and to a global defect in Th1-cell effector functions. Here we report that the Th2 cytokine response, which begins 6 weeks after infection, at the time of parasite egg laying (i) does not occur in the context of a genuine Th1 to Th2 cytokine switch, but is associated… CONTINUE READING

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