Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells.

@article{Lu1995Interleukin10IA,
  title={Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells.},
  author={Zhao Yang Lu and X G Zhang and C Rodr{\'i}guez and John Wijdenes and Z. John Gu and B Morel-Fournier and J. L. Harousseau and R{\'e}gis Bataille and Jean François Rossi and Bernard Klein},
  journal={Blood},
  year={1995},
  volume={85 9},
  pages={2521-7}
}
Because interleukin-10 (IL-10) is a potent differentiation factor of human B cells into mature plasma cells, we investigated its effect on human malignant plasma cells. IL-10 did not induce any differentiation and increase in Ig synthesis in four human IL-6-dependent malignant plasma cell lines. However, it stimulated the proliferation of two of four cytokine-dependent cell lines in the absence of IL-6 and IL-10-dependent myeloma cell lines have been obtained. The myeloma cell growth activity… CONTINUE READING