Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules.

@article{Yue1997Interleukin10IA,
  title={Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules.},
  author={Feng Yun Yue and Reinhard Dummer and Ralf Geertsen and G{\"u}nther F. L. Hofbauer and Elisabeth Laine and S Manolio and Guenter Burg},
  journal={International journal of cancer},
  year={1997},
  volume={71 4},
  pages={630-7}
}
IL-10 is a cytokine which shows various effects including inhibition of T-cell proliferation or HLA-dependent antigen presentation. In this study, we analysed the effects of exogenous or autocrine IL-10 on proliferation and expression of immunocritical surface molecules. Fourteen cultures of human melanoma cells were established from primary melanomas, locoregional lymph-node or distant metastases. In 5 melanoma cell cultures, proliferation in the presence of IL-10, anti-IL-10 antibodies (Ab… CONTINUE READING