Interleukin-10 inhibits interleukin-2-induced tumor necrosis factor production but does not reduce toxicity in C3H/HeN mice.

@article{Lentsch1996Interleukin10II,
  title={Interleukin-10 inhibits interleukin-2-induced tumor necrosis factor production but does not reduce toxicity in C3H/HeN mice.},
  author={Alex B. Lentsch and Michael J. Edwards and David E. Sims and Kazunori Nakagawa and Samuel R. Wellhausen and Frederick N. Miller},
  journal={Journal of leukocyte biology},
  year={1996},
  volume={60 1},
  pages={51-7}
}
Immunotherapy with interleukin-2 (IL-2) is limited by severe side effects thought to be mediated by the activation of immune effector cells and the induction of secondary cytokines including tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). In C3H/HeN mice the primary IL-2 toxicity is the production of pleural effusion with… CONTINUE READING

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