Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current.

  title={Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current.},
  author={Nan Jiang and Peng Shi and Fiona Desland and M Cristina Kitchen-Pareja and Colin Sumners},
  journal={American journal of physiology. Cell physiology},
  volume={304 8},
Previously we demonstrated that viral-mediated increased expression of the anti-inflammatory cytokine interleukin-10 within the paraventricular nucleus of the hypothalamus significantly reduces blood pressure in normal rats made hypertensive by infusion of angiotensin II. However, the exact cellular locus of this interleukin-10 action within the paraventricular nucleus is unknown. In the present study we tested whether interleukin-10 exerts direct effects at its receptors located on… CONTINUE READING


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