Interleukin-10 inhibition of HLA-DR expression in human herpes stromal keratitis.

  title={Interleukin-10 inhibition of HLA-DR expression in human herpes stromal keratitis.},
  author={Seymour Boorstein and Susan G. Elner and Roger F. Meyer and Alan Sugar and Robert M. Strieter and Steven L. Kunkel and Victor M. Elner},
  volume={101 9},
PURPOSE Human herpes stromal keratitis (HSK) is an important cause of visual loss and morbidity. The presentation of corneal and/or viral antigens is thought to activate T lymphocytes, resulting in aberrant cell-mediated immune responses that are central to the pathogenesis of HSK. Aberrant cellular expression of HLA-DR and intercellular adhesion molecule-1 (ICAM-1), both of which are necessary for optimal antigen-induced T-lymphocyte responses, is present in lesions of HSK, but little is known… CONTINUE READING


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